A catastrophic fault

On 19 September 2008 a simple electrical short caused an enormous disaster at the Large Hadron Collider (LHC) at CERN in Geneva. What happened was the loss of capability to carry current due to warm between superconducting cables and connections. After electrical short, thousand of litres of liquid helium expanded into the ultra-clean beam line and ripped magnets from their strands.

 

Replication timing analysis

The replication timing assay is a current lab method used to determine the exact phases of replication process. Exponentially growing cells are labelled with 5- bromo 2-deoxyuridine to mark newly generated cells. Indeed, the bromo-deoxyuridine is incorporated into DNA in place of thymidine.

 

Ten years after the Human Genome Project

The Human Genome Project started ten years ago, with the challenging promise to sequence the whole genome and definitively understand all genetic secrets.

 

Novel molecules to fight Pseudomonas

Infections are the most dangerous and common problems in hospital wards. Patients are weak and ill and their bodies are easily infected by opportunistic parasites. Pseudomonas Aeruginosa is a Gram negative bacterium that is responsible for the major part of nosocomial infections. In US at least 160000 patients are contaminated by Pseudomonas every year. Usual treatment is a course of antibiotics, but the presence of resistant strains often makes useless the therapy.

 

Mosaic vaccine for HIV

Mosaic vaccines are synthetic peptides, generated by an algorithm that cover all combinations of known sequences of HIV antigen. The most challenging problem to solve in order to produce an effective vaccine against HIV is the high rate of variability in viral genome. Indeed, viruses tend to mutate rapidly to prevent the host’s immune defences; variations between individuals and different regions have been also reported.

 

Acute gastroenteritis in children

Acute gastroenteritis affects numerous children at least one time in their infancy and childhood. This disease is usually due to viral infection and none treatment is suggested to treat the infection self. In contrast, more concerns are due to dehydration associated with vomiting and diarrhoea.

 

Novel technique to diffract molecules

Ankylography is a novel technique that is setting up to determine the three-dimensional structure of proteins or in general macromolecules. This technique is based on the opportunity to measure the diffraction pattern through a spherical detector.

 

The IntOGen interface

Sometimes, there is a gap between experimental biology and clinical medicine while a continuous interchange would be auspicial to well direct experiments and keep updated the therapies. An interesting tool has been developed at the Barcelona Medical Research Park (Spain).

 

Application of molecular biology to medicine

Modern medicine is based on evidence. Despite few years ago, physicians based their diagnosis and therapies on their previous experiences, now clinical trials, approved protocols and worldwide accepted treatment help physicians to make the better choice for their patients. To reach this important goal, molecular medicine gave a big contribution. Molecular medicine is a novel branch of medicine in which molecular biology or biochemistry techniques are usually used to accomplish exams and screening or diagnose the diseases.

 

Nuocytes, a novel cell type

A recent work published in Nature demonstrates the existence of a new class of cells, namely noucytes. This cells seem really important for the type II immuninity. The type II immunity protects our body from parasitic helminth infections, by promoting the release of type II cytokines, activating eosinophiles and goblet cells and secreting mucus and IgE.

 
Syndicate content